Oxidative stress in obstructive sleep apnoea

Anna Svatikova, Robert Wolk, Lilach O. Lerman, Luis A. Juncos, Eddie L. Greene, Joseph P. McConnell, Virend K. Somers

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


Aims: Any sustained elevation of oxidative stress in patients with obstructive sleep apnoea (OSA) might help explain their increased risk for cardiovascular diseases. We tested the hypothesis that measures of oxidative stress are increased in otherwise healthy subjects with OSA when compared to closely matched OSA-free control subjects. Methods and results: Plasma indices of oxidative stress and lipid peroxidation [thiobarbituric acid-reactive substances (TBARS), oxidized LDL (oxLDL), isoprostanes] were measured in 41 moderate-severe OSA males without other diseases and in 35 matched controls first before sleep, then after 4 h of untreated OSA, and again in the morning after 4 h of effective treatment with continuous positive airway pressure (CPAP). Plasma levels of oxLDL, TBARS, and isoprostanes in OSA patients (n = 34, 26, 17, respectively) were comparable to the controls (n = 28, 27, 15 for the three markers, respectively). Neither untreated OSA nor CPAP treatment nor normal sleep affected levels of any of the three measures of oxidative stress. There was no association between the severity of sleep apnoea and any measure of oxidative stress. Conclusion: Otherwise healthy OSA patients, without any other co-morbidities, do not manifest evidence for higher oxidative stress and lipid peroxidation. Thus, oxidative stress and lipid peroxidation do not appear to be key mediators of increased cardiovascular disease in OSA patients.

Original languageEnglish (US)
Pages (from-to)2435-2439
Number of pages5
JournalEuropean heart journal
Issue number22
StatePublished - Nov 2005


  • Cardiovascular diseases
  • Isoprostanes
  • Obstructive sleep apnoea
  • Oxidative stress
  • oxLDL

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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