Overview of Treatment Approaches for Fungal Infections

Eva M. Carmona; Andrew H. Limper

doi:10.1016/j.ccm.2017.04.003

Overview of Treatment Approaches for Fungal Infections

Eva M. Carmona, Andrew H. Limper

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Invasive fungal diseases cause high morbidity and mortality in an immunocompromised host. Antifungals are the drugs of choice and can be divided into 4 main groups: polyenes, azoles, echinocandins, and pyrimidine analogues. Each class has its specific mechanism of action, spectrum of activity, and pharmacokinetic and side effects. It is important to understand the precise use of the established and new antifungal agents to successfully manage these complex infections in an already tenuous and frail host. This article discusses the main characteristics, clinical uses, and secondary effects of the main antifungals used in clinical practice.

Original language	English (US)
Pages (from-to)	393-402
Number of pages	10
Journal	Clinics in Chest Medicine
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.ccm.2017.04.003
State	Published - Sep 2017

Keywords

Amphotericin
Antifungal
Echinocandins
Flucytosine
Fungal infections
Invasive mycoses
Triazoles

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.ccm.2017.04.003

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title = "Overview of Treatment Approaches for Fungal Infections",

abstract = "Invasive fungal diseases cause high morbidity and mortality in an immunocompromised host. Antifungals are the drugs of choice and can be divided into 4 main groups: polyenes, azoles, echinocandins, and pyrimidine analogues. Each class has its specific mechanism of action, spectrum of activity, and pharmacokinetic and side effects. It is important to understand the precise use of the established and new antifungal agents to successfully manage these complex infections in an already tenuous and frail host. This article discusses the main characteristics, clinical uses, and secondary effects of the main antifungals used in clinical practice.",

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AU - Carmona, Eva M.

AU - Limper, Andrew H.

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AB - Invasive fungal diseases cause high morbidity and mortality in an immunocompromised host. Antifungals are the drugs of choice and can be divided into 4 main groups: polyenes, azoles, echinocandins, and pyrimidine analogues. Each class has its specific mechanism of action, spectrum of activity, and pharmacokinetic and side effects. It is important to understand the precise use of the established and new antifungal agents to successfully manage these complex infections in an already tenuous and frail host. This article discusses the main characteristics, clinical uses, and secondary effects of the main antifungals used in clinical practice.

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KW - Echinocandins

KW - Flucytosine

KW - Fungal infections

KW - Invasive mycoses

KW - Triazoles

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Overview of Treatment Approaches for Fungal Infections

Abstract

Keywords

ASJC Scopus subject areas

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