Overview: Gastrointestinal manifestations and management

Seth Sweetser, Michael Camilleri

Research output: Chapter in Book/Report/Conference proceedingChapter


Systemic sclerosis (SSc, scleroderma) is a chronic, connective tissue disease characterized by vascular damage and fibrosis of the skin and internal organs including the gastrointestinal (GI) tract. After skin involvement, the GI tract is the second most commonly involved organ system with the esophagus being the most frequent segment involved. Involvement of the stomach, small intestine, colon, and anorectum is less common but may lead to severe complications and debility. Ultimately, over 80% of individuals with scleroderma will experience a change in normal GI function [1, 2].

Original languageEnglish (US)
Title of host publicationScleroderma
Subtitle of host publicationFrom Pathogenesis to Comprehensive Management
PublisherSpringer US
Number of pages7
ISBN (Electronic)9781441957740
ISBN (Print)9781441957733
StatePublished - Jan 1 2012


  • Gastrointestinal management
  • Gastrointestinal manifestations
  • Overview
  • Pathogenesis
  • Pathology
  • Prevalence of gastrointestinal symptoms
  • Stomach involvement

ASJC Scopus subject areas

  • General Medicine


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