Kenneth D. Hopper, Richard P. Moser, David B. Haseman, Donald E. Sweet, John E. Madewell, Mark J. Kransdorf

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


A review of the 690 cases of osteosarcoma in the radiographic file of the Armed Forces Institute of Pathology revealed 29 cases of "osteosarcomatosis" (multiple skeletal sites of osteosarcoma). Fifteen of these patients were 18 years old and under and manifested rapidly appearing, usually symmetric, sclerotic metaphyseal lesions. The remaining 14 patients were more than 18 years old and had fewer, asymmetric sclerotic lesions. In most patients (28 of 29), a radiographically dominant skeletal tumor was seen. Pulmonary métastases occurred in the majority of patients and were detected at the same time as the bone lesions. These 29 patients were studied with regard to demographic data and skeletal distribution and radiographic appearance of their lesions. As a result of the findings, a metastatic origin from a primary dominant osteosarcoma is favored over a multifocal origin as the basis for osteosarcomatosis. Osteosarcomatosis is more commonly encountered in the mature skeleton than has been previously recognized.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
Issue number1
StatePublished - Apr 1990


  • Bone neoplasms, 40.3221
  • Bone neoplasms, metastases, 40.3221
  • Bone neoplasms, secondary, 10.33, 20.33, 30.33, 40.33
  • Lung neoplasms, secondary, 60.33
  • Osteosarcoma, 10.33, 20.33, 30.33, 40.3221, 40.33

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Osteosarcomatosis'. Together they form a unique fingerprint.

Cite this