Organizing diffuse alveolar damage associated with progressive systemic sclerosis

Trudie E. Mum, Henry D. Tazelaar, Thomas V. Colby, Jeffrey L. Myers

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Diffuse alveolar damage (DAD) is a relatively nonspecific pattern of acute lung injury that can be observed in a wide range of clinical circumstances. DAD has often been recognized in association with various connective tissue diseases; however, to our knowledge, it has not been previously reported in the setting of progressive systemic sclerosis. Herein we describe two patients with established diagnoses of progressive systemic sclerosis who had development of the acute respiratory distress syndrome. Open-lung biopsy specimens from both patients showed a histologic pattern of DAD with no identifiable cause other than their progressive systemic sclerosis. Our results suggest that DAD should be added to the list of pleuropulmonary complications of progressive systemic sclerosis.

Original languageEnglish (US)
Pages (from-to)639-642
Number of pages4
JournalMayo Clinic proceedings
Issue number7
StatePublished - 1997

ASJC Scopus subject areas

  • General Medicine


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