Oral Signs of Vesiculobullous and Autoimmune Disease

Michael Z. Wang, Julia S. Lehman, Roy Steele Rogers

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter is focused on the oral manifestations of vesiculobullous and autoimmune diseases. These diseases often share similar oral presentations with subtle differences. Therefore, eliciting a detailed medical history and a thorough oral examination are necessary, while supporting tests including serologies, biopsies, as well as direct and indirect immunofluorescence are often valuable. Examination of cutaneous skin and non-oral mucosa may offer additional diagnostic and prognostic insights. Oral vesiculobullous and autoimmune diseases can lead to debilitating morbidities such as pain and poor oral intake. These diseases may also serve as windows to internal diseases such as infection and malignancy, which necessitates multidisciplinary care. This chapter describes the epidemiology, etiopathogenesis, clinical manifestations, differential diagnosis, and treatments of oral vesiculobullous and autoimmune diseases, with an emphasis on their oral signs and symptoms.

Original languageEnglish (US)
Title of host publicationOral Signs of Systemic Disease
PublisherSpringer International Publishing
Number of pages32
ISBN (Electronic)9783030108632
ISBN (Print)9783030108618
StatePublished - Jan 1 2019


  • Angina bullosa hemorrhagica
  • Autoimmune
  • Dermatitis herpetiformis
  • Epidermolysis bullosa
  • Erythema multiforme
  • Lichen planus
  • Linear IgA bullous dermatosis
  • Paraneoplastic
  • Pemphigoid
  • Pemphigus
  • Steven Johnson syndrome
  • Toxic epidermal necrolysis
  • Vesiculobullous
  • Vitiligo

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)


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