Abstract
Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.
Original language | English (US) |
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Pages (from-to) | 638-641 |
Number of pages | 4 |
Journal | Cancer Gene Therapy |
Volume | 20 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2013 |
Keywords
- NIS
- barium sulfate
- oral contrast
- perigastric
- reporter gene
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Cancer Research