Optimizing molecular signatures for predicting prostate cancer recurrence

Yijun Sun, Steve Goodison

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


BACKGROUND. The derivation of molecular signatures indicative of disease status and predictive of subsequent behavior could facilitate the optimal choice of treatment for prostate cancer patients. METHODS. In this study, we conducted a computational analysis of gene expression profile data obtained from 79 cases, 39 of which were classified as having disease recurrence, to investigate whether advanced computational algorithms can derive more accurate prognostic signatures for prostate cancer. RESULTS. At the 90% sensitivity level, a newly derived prognostic genetic signature achieved 85% specificity. This is the first reported genetic signature to outperform a clinically used postoperative nomogram. Furthermore, a hybrid prognostic signature derived by combination of the nomogram and gene expression data significantly outperformed both genetic and clinical signatures, and achieved a specificity of 95%. CONCLUSIONS. Our study demonstrates the feasibility of utilizing gene expression information for highly accurate prostate cancer prognosis beyond the current clinical systems, and shows that more advanced computational modeling of tissue-derived microarray data is warranted before clinical application of molecular signatures is considered.

Original languageEnglish (US)
Pages (from-to)1119-1127
Number of pages9
Issue number10
StatePublished - Jul 1 2009


  • Microarray
  • Nomogram
  • Predictive model
  • Prostate cancer prognosis

ASJC Scopus subject areas

  • Oncology
  • Urology


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