Operating behavior of dual or multiple endocrine pulse generators

J. D. Veldhuis, A. E. Lassiter, M. L. Johnson

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


We describe an endocrine model of dual or multiple stochastic generators of episodic pulse signals, provide a sensitivity analysis of output responses, and illustrate the statistical effects of a plurality of independent pulse generators on peak detector performance (sensitivity, specificity, positive accuracy, and negative accuracy). We define the probability distribution of random summation or interference events and evaluate physiological implications of two or more interacting pulse-generator systems. Such observations offer a basis for quantitative examination of the operating characteristics of two or more interacting endocrine pulse generators in specified physiological contexts.

Original languageEnglish (US)
Pages (from-to)E351-E361
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number3 22-3
StatePublished - 1990


  • Analysis
  • Deconvolution
  • Episodic secretion
  • False negative
  • False positive
  • Hormone
  • Metabolic clearance
  • Peak
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


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