Olfactory dysfunction in familial parkinsonism

K. Markopoulou, K. W. Larsen, E. K. Wszolek, M. A. Denson, A. E. Lang, R. F. Pfeiffer, Z. K. Wszolek

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Impaired olfactory function is commonly observed in idiopathic Parkinson's disease (IPD). However, it is unknown whether it is also found in familial parkinsonism. To address this issue we administered a smell test to 12 affected, three monosymptomatic, and 12 at-risk individuals from six large parkinsonian kindreds. Three kindreds exhibited an IPD phenotype and three exhibited a parkinsonism-plus syndrome (PPS) phenotype. All but one of the affected individuals had impaired olfactory function. In contrast, only five of the 12 at-risk individuals had impaired olfactory function. The degree of olfactory impairment in the at-risk individuals was less severe than in the affected individuals. The difference in the degree of olfactory impairment in individuals exhibiting the IPD and the PPS phenotypes was not statistically significant. These findings suggest that olfactory dysfunction is a phenotypic characteristic of familial parkinsonism and that it is independent of the kindred phenotype. The appearance of olfactory dysfunction soon after disease onset raises the possibility that it is part of the neurodegenerative disease process.

Original languageEnglish (US)
Pages (from-to)1262-1267
Number of pages6
Issue number5
StatePublished - Nov 1997

ASJC Scopus subject areas

  • Clinical Neurology


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