Olfactory Dysfunction

Andreas Puschmann; Zbigniew K. Wszolek

doi:10.1007/978-1-60761-429-6_23

Olfactory Dysfunction

Andreas Puschmann, Zbigniew K. Wszolek

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Olfactory dysfunction is well documented as an early nonmotor manifestation of Parkinson's disease (PD). This chapter outlines the anatomy and physiology of the olfactory system and summarizes the pathological changes in the olfactory system in PD. We review the occurrence of -olfactory dysfunction in parkinsonian syndromes and familial parkinsonism. Different methods to assess olfactory function are presented. Their usefulness in routine clinical situations is limited to special diagnostic situations. However, these methods have provided important insights into the pathophysiology of parkinsonism and can help to identify at-risk groups for future neuroprotective trials. Several lines of evidence now suggest that olfactory disturbance reflects Lewy pathology more closely than it reflects striatonigral dopamine deficiency.

Original language	English (US)
Title of host publication	Parkinson's Disease and Nonmotor Dysfunction
Publisher	Springer Basel
Pages	335-348
Number of pages	14
ISBN (Print)	9781607614289
DOIs	https://doi.org/10.1007/978-1-60761-429-6_23
State	Published - 2013

Publication series

Name	Milestones in Drug Therapy
Volume	24
ISSN (Print)	2296-6056

Keywords

Hyposmia
Olfaction
Olfactory nerve
Parkinson's disease

ASJC Scopus subject areas

Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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10.1007/978-1-60761-429-6_23

Cite this

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AB - Olfactory dysfunction is well documented as an early nonmotor manifestation of Parkinson's disease (PD). This chapter outlines the anatomy and physiology of the olfactory system and summarizes the pathological changes in the olfactory system in PD. We review the occurrence of -olfactory dysfunction in parkinsonian syndromes and familial parkinsonism. Different methods to assess olfactory function are presented. Their usefulness in routine clinical situations is limited to special diagnostic situations. However, these methods have provided important insights into the pathophysiology of parkinsonism and can help to identify at-risk groups for future neuroprotective trials. Several lines of evidence now suggest that olfactory disturbance reflects Lewy pathology more closely than it reflects striatonigral dopamine deficiency.

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Olfactory Dysfunction

Abstract

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Keywords

ASJC Scopus subject areas

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