Ocular graft-versus-host disease: A review

Saranya C. Balasubramaniam, Harish Raja, Cherie B. Nau, Joanne F. Shen, Muriel M. Schornack

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Hematopoietic stem cell transplantation is important in the management of several lymphoproliferative and bone marrow disorders. Graft-versus-host disease (GVHD) involves inflammatory manifestations that arise after transplant and can affect many organs. Ocular manifestations of GVHD are common, and eye care providers must understand this disease entity. The ocular surface is most commonly involved, but GVHD can affect all parts of the eye. Ocular GVHD can be relapsing and remitting, can decrease quality of life, and can be challenging to diagnose and adequately treat. The diagnostic criteria for and grading of ocular GVHD continue to evolve. This review aims to summarize current definitions, clinical findings, diagnostic criteria, and management of ocular GVHD. The care of patients with ocular GVHD requires a multidisciplinary approach.

Original languageEnglish (US)
Pages (from-to)256-261
Number of pages6
JournalEye and Contact Lens
Issue number5
StatePublished - Sep 11 2015


  • Dry eye syndrome
  • Graft-versus-host disease
  • Keratoconjunctivitis sicca
  • Scleral lenses
  • Stem cell transplant

ASJC Scopus subject areas

  • Ophthalmology


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