TY - JOUR
T1 - Obstructive sleep apnea, cardiovascular disease, and pulmonary hypertension
AU - Golbin, Jason M.
AU - Somers, Virend K.
AU - Caples, Sean M.
PY - 2008/2
Y1 - 2008/2
N2 - With the growing epidemic of obesity in an aging population, obstructive sleep apnea (OSA) is increasingly encountered in clinical practice. Given the acute cardiopulmonary stressors consequent to repetitive upper airway collapse, as well as evidence for cardiovascular homeostatic dysregulation in subjects with sleep apnea, there is ample biologic plausibility that OSA imparts increased cardiovascular risk, independent of comorbid disease. Indeed, observational studies have suggested strong associations with multiple disorders, such as systemic hypertension, heart failure, cardiac arrhythmias, and pulmonary hypertension. Further data in the form of longitudinal cohort studies and randomized controlled trials are accruing to add to the body of evidence. This review examines pathophysiologic mechanisms and explores current concepts regarding the impact of OSA and its treatment on selected clinical disease states.
AB - With the growing epidemic of obesity in an aging population, obstructive sleep apnea (OSA) is increasingly encountered in clinical practice. Given the acute cardiopulmonary stressors consequent to repetitive upper airway collapse, as well as evidence for cardiovascular homeostatic dysregulation in subjects with sleep apnea, there is ample biologic plausibility that OSA imparts increased cardiovascular risk, independent of comorbid disease. Indeed, observational studies have suggested strong associations with multiple disorders, such as systemic hypertension, heart failure, cardiac arrhythmias, and pulmonary hypertension. Further data in the form of longitudinal cohort studies and randomized controlled trials are accruing to add to the body of evidence. This review examines pathophysiologic mechanisms and explores current concepts regarding the impact of OSA and its treatment on selected clinical disease states.
KW - Arrhythmia
KW - Positive airway pressure
KW - Sleep-disordered breathing
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=39049087089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049087089&partnerID=8YFLogxK
U2 - 10.1513/pats.200708-143MG
DO - 10.1513/pats.200708-143MG
M3 - Review article
C2 - 18250213
AN - SCOPUS:39049087089
SN - 1546-3222
VL - 5
SP - 200
EP - 206
JO - Proceedings of the American Thoracic Society
JF - Proceedings of the American Thoracic Society
IS - 2
ER -