Obstructive sleep apnea as a cause of neurogenic hypertension

Krzysztof Narkiewicz; Virend K. Somers

doi:10.1007/s11906-999-0032-7

Obstructive sleep apnea as a cause of neurogenic hypertension

Krzysztof Narkiewicz, Virend K. Somers

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Abnormalities in neural circulatory control may contribute importantly to the hypertensive state. The sympathetic nervous system in particular is a key mechanism for increasing blood pressure. Patients with obstructive sleep apnea have increased sympathetic activity. Obesity or other coexisting disease states do not explain the heightened sympathetic drive. This review examines the evidence linking sleep apnea with hypertension and the possible role of excessive sympathetic drive as a mediator of higher blood pressure in sleep apnea. Abnormalities in reflex circulatory control that could act to increase sympathetic activity in sleep apnea are also discussed.

Original language	English (US)
Pages (from-to)	268-273
Number of pages	6
Journal	Current Hypertension Reports
Volume	1
Issue number	3
DOIs	https://doi.org/10.1007/s11906-999-0032-7
State	Published - 1999

ASJC Scopus subject areas

Internal Medicine

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10.1007/s11906-999-0032-7

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title = "Obstructive sleep apnea as a cause of neurogenic hypertension",

abstract = "Abnormalities in neural circulatory control may contribute importantly to the hypertensive state. The sympathetic nervous system in particular is a key mechanism for increasing blood pressure. Patients with obstructive sleep apnea have increased sympathetic activity. Obesity or other coexisting disease states do not explain the heightened sympathetic drive. This review examines the evidence linking sleep apnea with hypertension and the possible role of excessive sympathetic drive as a mediator of higher blood pressure in sleep apnea. Abnormalities in reflex circulatory control that could act to increase sympathetic activity in sleep apnea are also discussed.",

author = "Krzysztof Narkiewicz and Somers, {Virend K.}",

note = "Funding Information: Dr. Narkiewicz, a Visiting Research Scientist from the Department of Hypertension and Diabetology, Medical School of Gdansk, Poland, is a recipient of an International Research John E. Fogarty Fellowship and a Perkins Memorial Award from the American Physiological Society. Dr. Somers is supported by a Sleep Academic Award, and grants HL61560 and HL60618 from the National Institue of Health, and is an Established Investigator of the American Heart Association.",

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AU - Somers, Virend K.

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PY - 1999

Y1 - 1999

N2 - Abnormalities in neural circulatory control may contribute importantly to the hypertensive state. The sympathetic nervous system in particular is a key mechanism for increasing blood pressure. Patients with obstructive sleep apnea have increased sympathetic activity. Obesity or other coexisting disease states do not explain the heightened sympathetic drive. This review examines the evidence linking sleep apnea with hypertension and the possible role of excessive sympathetic drive as a mediator of higher blood pressure in sleep apnea. Abnormalities in reflex circulatory control that could act to increase sympathetic activity in sleep apnea are also discussed.

AB - Abnormalities in neural circulatory control may contribute importantly to the hypertensive state. The sympathetic nervous system in particular is a key mechanism for increasing blood pressure. Patients with obstructive sleep apnea have increased sympathetic activity. Obesity or other coexisting disease states do not explain the heightened sympathetic drive. This review examines the evidence linking sleep apnea with hypertension and the possible role of excessive sympathetic drive as a mediator of higher blood pressure in sleep apnea. Abnormalities in reflex circulatory control that could act to increase sympathetic activity in sleep apnea are also discussed.

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Obstructive sleep apnea as a cause of neurogenic hypertension

Abstract

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