Obstructive sleep apnea and hypertension

Krzysztof Narkiewicz, Jacek Wolf, Francisco Lopez-Jimenez, Virend K. Somers

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


There is growing evidence of a causal relationship between obstructive sleep apnea (OSA) and hypertension. Untreated OSA may have direct and deleterious effects on cardiovascular function and structure through several mechanisms, including sympathetic activation, oxidative stress, inflammation, and endothelial dysfunction. OSA may contribute to or augment elevated blood pressure levels in a large proportion of the hypertensive patient population. It is important to consider OSA in the differential diagnosis of hypertensive patients who are obese. OSA should be especially considered in those hypertensive patients who respond poorly to combination therapy with antihypertensive medications.

Original languageEnglish (US)
Pages (from-to)435-440
Number of pages6
JournalCurrent cardiology reports
Issue number6
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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