Obese Patients Undergoing Ileal Pouch-Anal Anastomosis

Nicholas P. McKenna, Kellie L. Mathis, Mohammad A. Khasawneh, Eric J. Dozois, David W. Larson, John H. Pemberton, Amy L. Lightner

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background: Ileal pouch–anal anastomosis (IPAA) is the preferred surgical treatment for patients with chronic ulcerative colitis. Little is known about the impact of obesity on operative characteristics, short-term postoperative complications and long-term functional outcomes after IPAA. Methods: A retrospective review of all patients undergoing IPAA for chronic ulcerative colitis at a single tertiary referral center between January 2002 and August 2013 was performed. Thirty-day postoperative complications and long-term functional outcomes were analyzed according to body mass index. Results: Nine hundred nine IPAAs (154 obese [body mass index $ 30] and 755 not obese [body mass index , 30]) were performed during the study period. For 2-stage IPAA, obese patients were less likely to undergo laparoscopic IPAA (P , 0.0001), had greater estimated blood loss (P ¼ 0.005), and longer operative times (P ¼ 0.02). For 3-stage IPAA, obese patients were less likely to undergo a laparoscopic procedure (P ¼ 0.03), had greater estimated blood loss (P , 0.0001), and longer operative times (P ¼ 0.0002). Postoperatively, obese patients had a longer length of stay after a 2-stage procedure (P ¼ 0.009), an increased rate of superficial surgical site infections (P ¼ 0.003), and an increased rate of urinary tract infections (P ¼ 0.03). Of the 61% (n ¼ 546) of patients with IPAA with long-term (median 5.0 years) follow-up, there were no significant differences in functional outcomes including incontinence, frequency of bowel movements, pad usage, and pouchitis between the groups. Conclusions: Obesity impacts intraoperative complexity and 30-day postoperative outcomes. Long-term functional outcomes are not affected. These findings underscore the need to counsel patients on preoperative weight loss before undergoing elective IPAA.

Original languageEnglish (US)
Pages (from-to)2142-2146
Number of pages5
JournalInflammatory bowel diseases
Issue number12
StatePublished - 2017


  • CUC
  • IPAA
  • obesity
  • surgery

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology


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