Nutrition interventions in congenital disorders of glycosylation

Suzanne W. Boyer, Christin Johnsen, Eva Morava

Research output: Contribution to journalReview articlepeer-review


Congenital disorders of glycosylation (CDG) are a group of more than 160 inborn errors of metabolism affecting multiple pathways of protein and lipid glycosylation. Patients present with a wide range of symptoms and therapies are only available for very few subtypes. Specific nutritional treatment options for certain CDG types include oral supplementation of monosaccharide sugars, manganese, uridine, or pyridoxine. Additional management includes specific diets (i.e., complex carbohydrate or ketogenic diet), iron supplementation, and albumin infusions. We review the dietary management in CDG with a focus on two subgroups: N-linked glycosylation defects and GPI-anchor disorders.

Original languageEnglish (US)
Pages (from-to)463-481
Number of pages19
JournalTrends in Molecular Medicine
Issue number6
StatePublished - Jun 2022


  • GPI-anchor disorder
  • N-linked CDG
  • hypoglycemia
  • manganese
  • monosaccharide therapy
  • pyridoxine

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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