Nuclear dynamics and chromatin structure: Implications for pancreatic cancer

Luis F. Flores, Brooke R. Tader, Ezequiel J. Tolosa, Ashley N. Sigafoos, David L. Marks, Martin E. Fernandez-Zapico

Research output: Contribution to journalReview articlepeer-review


Changes in nuclear shape have been extensively associated with the dynamics and functionality of cancer cells. In most normal cells, nuclei have a regular ellipsoid shape and minimal variation in nuclear size; however, an irregular nuclear contour and abnormal nuclear size is often observed in cancer, including pancreatic cancer. Furthermore, alterations in nuclear morphology have become the ‘gold standard’ for tumor staging and grading. Beyond the utility of altered nuclear morphology as a diagnostic tool in cancer, the implications of altered nuclear structure for the biology and behavior of cancer cells are profound as changes in nuclear morphology could impact cellular responses to physical strain, adaptation during migration, chromatin organization, and gene expression. Here, we aim to highlight and discuss the factors that regulate nuclear dynamics and their implications for pancreatic cancer biology.

Original languageEnglish (US)
Article number2624
Issue number10
StatePublished - Oct 2021


  • Chromatin
  • Gene expression
  • Nuclear lamina
  • Nuclear morphology
  • Pancreatic cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Nuclear dynamics and chromatin structure: Implications for pancreatic cancer'. Together they form a unique fingerprint.

Cite this