Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization

Paul Fredrickson; Mona Boules; Sally Yerbury; Elliott Richelson

doi:10.1016/S0006-8993(03)02895-6

Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization

Paul Fredrickson, Mona Boules, Sally Yerbury, Elliott Richelson

Neuroscience

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated in nicotine addiction. Previously, we showed that one of our brain-penetrating neurotensin analogs, NT69L, blocks nicotine-induced locomotor sensitization. The present work demonstrates that NT69L blocks both the initiation and the expression of sensitization. In addition chronic NT69L administration blocked the acute effects of nicotine on norepinephrine and serotonin in prefrontal cortex.

Original language	English (US)
Pages (from-to)	245-248
Number of pages	4
Journal	Brain Research
Volume	979
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(03)02895-6
State	Published - Jul 25 2003

Keywords

NT69L
Neurotensin
Nicotine
Sensitization

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(03)02895-6

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title = "Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization",

abstract = "Neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated in nicotine addiction. Previously, we showed that one of our brain-penetrating neurotensin analogs, NT69L, blocks nicotine-induced locomotor sensitization. The present work demonstrates that NT69L blocks both the initiation and the expression of sensitization. In addition chronic NT69L administration blocked the acute effects of nicotine on norepinephrine and serotonin in prefrontal cortex.",

keywords = "NT69L, Neurotensin, Nicotine, Sensitization",

author = "Paul Fredrickson and Mona Boules and Sally Yerbury and Elliott Richelson",

note = "Funding Information: This work was funded by grant MH27692 from the National Institute of Mental Health, the Forrest C. Lattner Foundation, Inc. and by the Mayo Foundation for Medical Education and Research.",

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T1 - Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization

AU - Fredrickson, Paul

AU - Boules, Mona

AU - Yerbury, Sally

AU - Richelson, Elliott

N1 - Funding Information: This work was funded by grant MH27692 from the National Institute of Mental Health, the Forrest C. Lattner Foundation, Inc. and by the Mayo Foundation for Medical Education and Research.

PY - 2003/7/25

Y1 - 2003/7/25

N2 - Neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated in nicotine addiction. Previously, we showed that one of our brain-penetrating neurotensin analogs, NT69L, blocks nicotine-induced locomotor sensitization. The present work demonstrates that NT69L blocks both the initiation and the expression of sensitization. In addition chronic NT69L administration blocked the acute effects of nicotine on norepinephrine and serotonin in prefrontal cortex.

AB - Neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated in nicotine addiction. Previously, we showed that one of our brain-penetrating neurotensin analogs, NT69L, blocks nicotine-induced locomotor sensitization. The present work demonstrates that NT69L blocks both the initiation and the expression of sensitization. In addition chronic NT69L administration blocked the acute effects of nicotine on norepinephrine and serotonin in prefrontal cortex.

KW - NT69L

KW - Neurotensin

KW - Nicotine

KW - Sensitization

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ER -

Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization

Abstract

Keywords

ASJC Scopus subject areas

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