Novel insights into the coupling of osteoclasts and resorption to bone formation

Margaret M. Durdan, Ruth D. Azaria, Megan M. Weivoda

Research output: Contribution to journalReview articlepeer-review


Bone remodeling consists of resorption by osteoclasts (OCs) and formation by osteoblasts (OBs). Precise coordination of these activities is required for the resorbed bone to be replaced with an equal amount of new bone in order to maintain skeletal mass throughout the lifespan. This coordination of remodeling processes is referred to as the “coupling” of resorption to bone formation. In this review, we discuss the essential role for OCs in coupling resorption to bone formation, mechanisms for this coupling, and how coupling becomes less efficient or disrupted in conditions of bone loss. Lastly, we provide perspectives on targeting coupling to treat human bone disease.

Original languageEnglish (US)
Pages (from-to)4-13
Number of pages10
JournalSeminars in Cell and Developmental Biology
StatePublished - Mar 2022


  • Bone formation
  • Bone remodeling
  • Coupling factor
  • Osteoclast
  • Resorption

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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