TY - JOUR
T1 - Not a usual suspect; rabeprazole therapy presenting as a severe neuropsychiatric illness
T2 - Case report
AU - Alfonzo, Christopher A.
AU - Bobo, William V.
AU - Almond, Myron D.
PY - 2003
Y1 - 2003
N2 - We report the case of a patient who, as a result of exposure to the proton pump inhibitor rabeprazole, developed a severe and disabling admixture of neuropsychiatric symptoms. Because of its widely appreciated placebo-like side effect profile, rabeprazole was never suspected as being the cause of his symptoms. Instead, a somatoform spectrum disorder was assigned based on the patient's atypical symptom presentation, progressive course, subjective psychological distress, intemperate consumption of healthcare resources over a relatively brief period of time and lack of any medical explanation for his symptoms at that time, despite exhaustive laboratory and radiologic work-ups. This case report reinforces the notion that even a medication such as rabeprazole, with an established safety and tolerability profile, may be associated with side effects severe enough to mimic disabling neuropsychiatric illness.
AB - We report the case of a patient who, as a result of exposure to the proton pump inhibitor rabeprazole, developed a severe and disabling admixture of neuropsychiatric symptoms. Because of its widely appreciated placebo-like side effect profile, rabeprazole was never suspected as being the cause of his symptoms. Instead, a somatoform spectrum disorder was assigned based on the patient's atypical symptom presentation, progressive course, subjective psychological distress, intemperate consumption of healthcare resources over a relatively brief period of time and lack of any medical explanation for his symptoms at that time, despite exhaustive laboratory and radiologic work-ups. This case report reinforces the notion that even a medication such as rabeprazole, with an established safety and tolerability profile, may be associated with side effects severe enough to mimic disabling neuropsychiatric illness.
KW - Adverse effects
KW - Neuropsychiatric
KW - Neuropsychological
KW - Proton pump inhibitors
KW - Rabeprazole
KW - Somatoform
UR - http://www.scopus.com/inward/record.url?scp=1542679813&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542679813&partnerID=8YFLogxK
U2 - 10.2190/KX4X-UFK5-60KL-WD2G
DO - 10.2190/KX4X-UFK5-60KL-WD2G
M3 - Article
C2 - 15089012
AN - SCOPUS:1542679813
SN - 0091-2174
VL - 33
SP - 311
EP - 315
JO - International Journal of Psychiatry in Medicine
JF - International Journal of Psychiatry in Medicine
IS - 3
ER -