Normative data for Aδ contact heat evoked potentials in adult population: A multicenter study

Yelena Granovsky, Praveen Anand, Aya Nakae, Osvaldo Nascimento, Benn Smith, Elliot Sprecher, Josep Valls-Solé

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


There has been a significant increase over recent years in the use of contact heat evoked potentials (CHEPs) for the evaluation of small nerve fiber function. Measuring CHEP amplitude and latency has clinical utility for the diagnosis and assessment of conditions with neuropathic pain. This international multicenter study aimed to provide reference values for CHEPs to stimuli at 5 commonly examined body sites. Contact heat evoked potentials were recorded from 226 subjects (114 females), distributed per age decade between 20 and 79 years. Temperature stimuli were delivered by a thermode (32°C-51°C at a rate of 70°C/s). In phase I of the study, we investigated side-to-side differences and reported the maximum normal side-to-side difference in Aδ CHEP peak latency and amplitude for leg, forearm, and face. In phase II, we obtained normative data for 3 CHEP parameters (N 2 P 2 amplitude, N 2 latency, and P 2 latency), stratified for gender and age decades from face, upper and lower limbs, and overlying cervical and lumbar spine. In general, larger CHEP amplitudes were associated with higher evoked pain scores. Females had CHEPs of larger amplitude and shorter latency than males. This substantive data set of normative values will facilitate the clinical use of CHEPs as a rapid, noninvasive, and objective technique for the assessment of patients presenting with neuropathic pain.

Original languageEnglish (US)
Pages (from-to)1156-1163
Number of pages8
Issue number5
StatePublished - May 1 2016


  • CHEPs
  • Nociceptive evoked potentials
  • Normative data

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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