Nonvasculitic autoimmune inflammatory meningoencephalitis (NAIM): A reversible form of encephalopathy

R. J. Caselli, B. F. Boeve, B. W. Scheithauer, J. D. O'Duffy, G. G. Hunder

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Five patients, age 54 to 80 years, presented between 3 weeks and 18 months after symptomatic onset of progressive cognitive decline, psychosis, and unsteady gait that proved to be due to a steroid-responsive nonvasculitic autoimmune inflammatory meningoencephalitic syndrome. CSF examination showed elevated immunoglobulin (Ig)G index and IgG synthesis rate in all three patients in whom it was checked, and brain biopsy revealed perivascular lymphocytic infiltrates without vessel wall invasion.

Original languageEnglish (US)
Pages (from-to)1579-1581
Number of pages3
Issue number7
StatePublished - Oct 22 1999


  • Autoimmunity
  • Dementia
  • Encephalopathy
  • Meningoencephalitis
  • Sjogren's syndrome

ASJC Scopus subject areas

  • Clinical Neurology


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