TY - JOUR
T1 - Noninvasive measurement of human ascending colon volume
AU - Badley, A. D.
AU - Camilleri, M.
AU - O'connor, M. K.
PY - 1993/6
Y1 - 1993/6
N2 - The capacitance and motor functions of the colon are important determinants of its overall function. A simple, noninvasive method to quantify regional colonic volume is required for further physiologic and pharmacologic studies. Our aim was to determine whether measurements of human ascending colon (AC) volume using two-dimensional (2-D) images are as accurate as estimates using three-dimensional (3-D) images. Five healthy male volunteers each ingested a methacrylate-coated capsule containing99Tcm-labelled Amberlite pellets. Two- and 3-D images were obtained using a gamma camera with single photon emission computed tomography (SPECT) capability. Ascending colon volume was estimated by a variable region of interest (VROI) program and by full-width half-maximum (FWHM) analysis, and results were compared to the volume estimates by SPECT. Full-width half-maximum analysis yielded volume estimates that were not significantly different from SPECT (slope = 1.093; t = 0.51; P>0.5), whereas VROI estimates were significantly different from volume measurements by SPECT and, hence, considered less accurate (slope = 0.438; t = 4.93; P<0.02). Thus, the less expensive and more easily available planar imaging technique with analysis by FWHM estimates AC volume as accurately as SPECT.
AB - The capacitance and motor functions of the colon are important determinants of its overall function. A simple, noninvasive method to quantify regional colonic volume is required for further physiologic and pharmacologic studies. Our aim was to determine whether measurements of human ascending colon (AC) volume using two-dimensional (2-D) images are as accurate as estimates using three-dimensional (3-D) images. Five healthy male volunteers each ingested a methacrylate-coated capsule containing99Tcm-labelled Amberlite pellets. Two- and 3-D images were obtained using a gamma camera with single photon emission computed tomography (SPECT) capability. Ascending colon volume was estimated by a variable region of interest (VROI) program and by full-width half-maximum (FWHM) analysis, and results were compared to the volume estimates by SPECT. Full-width half-maximum analysis yielded volume estimates that were not significantly different from SPECT (slope = 1.093; t = 0.51; P>0.5), whereas VROI estimates were significantly different from volume measurements by SPECT and, hence, considered less accurate (slope = 0.438; t = 4.93; P<0.02). Thus, the less expensive and more easily available planar imaging technique with analysis by FWHM estimates AC volume as accurately as SPECT.
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U2 - 10.1097/00006231-199306000-00012
DO - 10.1097/00006231-199306000-00012
M3 - Article
C2 - 8321488
AN - SCOPUS:0027195932
SN - 0143-3636
VL - 14
SP - 485
EP - 489
JO - Nuclear medicine communications
JF - Nuclear medicine communications
IS - 6
ER -