Non-neuroendocrine carcinomas (excluding sarcomatoid carcinoma) and salivary gland-type tumors of the lung

Lung cancer is the second most common cancer worldwide with over 2 million new cases in 2020 and is the number one cause of cancer death at 1.8 million according to the World Health Organization. Due to this frequency, lung specimens, either for diagnosis or at resection, are common in the pathology laboratory. This chapter is divided into four sections. In the first section, general considerations regarding the epidemiology, clinical presentation, and treatment of lung carcinomas will be introduced, followed by a discussion of specific subtypes of non-neuroendocrine, non-sarcomatoid lung carcinoma in the second section. The third and fourth sections will offer practical approaches to diagnosing lung carcinomas in small biopsies and surgical resections, respectively, discussing general considerations and addressing specific challenges commonly encountered with each of these two specimen types.