Nodular glomerulosclerosis in the nondiabetic smoker

Samih H. Nasr, Vivette D. D'Agati

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Emerging evidence supports that the entity known as idiopathic nodular glomerulosclerosis is not idiopathic. A strong causative association with longstanding cigarette smoking and hypertension has been identified. Morphologically, smoking-associated nodular glomerulosclerosis closely resembles diabetic nephropathy. The potential roles of advanced glycation end products, oxidative stress, angiogenesis, and hemodynamic perturbations are explored.

Original languageEnglish (US)
Pages (from-to)2032-2036
Number of pages5
JournalJournal of the American Society of Nephrology
Issue number7
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Nephrology


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