Nickel-induced changes and reappraisal of rosenthal fibers infocal CNS lesions

Dikran S. Horoupian, Yvonne Kress, Shu Hui Yen, Felicia Gaskin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Nickel (Ni) wire implants into the CNS of Lewis rats induce the formation of structures morphologically similar to Rosenthal fibers (RF) seen in human conditions. We describe in detail the time courses of Ni-induced changes in rat astrocytes and compare the Ni-induced RF with RF occurring in focal lesions. Immunocyto-chemistry at the level of electron microscopy suggests that the Ni-induced RF are largely made up of plasma proteins. We suggest that the mechanism of RF formation and possibly the protein composition of RF depends on the condition in which they are found.

Original languageEnglish (US)
Pages (from-to)664-675
Number of pages12
JournalJournal of Neuropathology and Experimental Neurology
Issue number6
StatePublished - Nov 1982


  • Alexander’s disease
  • Astrocytes
  • Glial fibrillary acidic protein
  • Glial filaments
  • Nickel
  • Plasma proteins
  • Rosenthal fibers

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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