New daily persistent headache: An update

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


New daily persistent headache is a primary headache disorder marked by a unique temporal profile which is daily from onset. For many sufferers this is their first ever headache. Very little is known about the pathogenesis of this condition. It might be a disorder of abnormal glial activation with persistent central nervous system inflammation and it may be a syndrome that occurs in individuals who have a history of cervical hypermobility. At present there is no known specific treatment and many patients go for years to decades without any improvement in their condition despite aggressive therapy. This article will present an up-to-date overview of new daily persistent headache on the topics of clinical presentation, treatment, diagnostic criteria, and presumed pathogenesis. It will also provide some of the authors own treatment suggestions based on recognized triggering events and some suggestions for future clinical trials.

Original languageEnglish (US)
Article number431
JournalCurrent pain and headache reports
Issue number7
StatePublished - Jul 2014


  • Chronic daily headache
  • Cytokines
  • Hypermobility
  • New daily persistent headache
  • Tumor necrosis factor alpha

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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