Neurotrophin Receptor Signaling

R. S. Kenchappa; B. D. Carter

doi:10.1016/B978-0-12-378630-2.00405-9

Neurotrophin Receptor Signaling

R. S. Kenchappa, B. D. Carter

Cancer Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The neurotrophins, nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 and -4, are a family of highly homologous proteins regulating neuronal survival and differentiation during the development of the vertebrate nervous system. They act through binding two types of receptors, a family of tyrosine kinase receptors, referred to as the Trks, and a member of the tumor necrosis factor receptor superfamily, p75NTR. This article discusses the mechanisms by which the receptors mediate the responses to neurotrophin or proneurotrophin binding.

Original language	English (US)
Title of host publication	Encyclopedia of Biological Chemistry
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	241-246
Number of pages	6
ISBN (Electronic)	9780123786319
ISBN (Print)	9780123786302
DOIs	https://doi.org/10.1016/B978-0-12-378630-2.00405-9
State	Published - Feb 15 2013

Keywords

Apoptosis
BDNF
Cell survival
Gamma-secretase
Neurotrophins
NGF
P75NTR
Phosphorylation
Proneurotrophins
Receptor
Signal transduction
Trk receptor

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/B978-0-12-378630-2.00405-9

Cite this

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title = "Neurotrophin Receptor Signaling",

abstract = "The neurotrophins, nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 and -4, are a family of highly homologous proteins regulating neuronal survival and differentiation during the development of the vertebrate nervous system. They act through binding two types of receptors, a family of tyrosine kinase receptors, referred to as the Trks, and a member of the tumor necrosis factor receptor superfamily, p75NTR. This article discusses the mechanisms by which the receptors mediate the responses to neurotrophin or proneurotrophin binding.",

keywords = "Apoptosis, BDNF, Cell survival, Gamma-secretase, Neurotrophins, NGF, P75NTR, Phosphorylation, Proneurotrophins, Receptor, Signal transduction, Trk receptor",

author = "Kenchappa, {R. S.} and Carter, {B. D.}",

year = "2013",

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day = "15",

doi = "10.1016/B978-0-12-378630-2.00405-9",

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T1 - Neurotrophin Receptor Signaling

AU - Kenchappa, R. S.

AU - Carter, B. D.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - The neurotrophins, nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 and -4, are a family of highly homologous proteins regulating neuronal survival and differentiation during the development of the vertebrate nervous system. They act through binding two types of receptors, a family of tyrosine kinase receptors, referred to as the Trks, and a member of the tumor necrosis factor receptor superfamily, p75NTR. This article discusses the mechanisms by which the receptors mediate the responses to neurotrophin or proneurotrophin binding.

AB - The neurotrophins, nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 and -4, are a family of highly homologous proteins regulating neuronal survival and differentiation during the development of the vertebrate nervous system. They act through binding two types of receptors, a family of tyrosine kinase receptors, referred to as the Trks, and a member of the tumor necrosis factor receptor superfamily, p75NTR. This article discusses the mechanisms by which the receptors mediate the responses to neurotrophin or proneurotrophin binding.

KW - Apoptosis

KW - BDNF

KW - Cell survival

KW - Gamma-secretase

KW - Neurotrophins

KW - NGF

KW - P75NTR

KW - Phosphorylation

KW - Proneurotrophins

KW - Receptor

KW - Signal transduction

KW - Trk receptor

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U2 - 10.1016/B978-0-12-378630-2.00405-9

DO - 10.1016/B978-0-12-378630-2.00405-9

M3 - Chapter

AN - SCOPUS:85042797552

SN - 9780123786302

SP - 241

EP - 246

BT - Encyclopedia of Biological Chemistry

PB - Elsevier Inc.

ER -

Neurotrophin Receptor Signaling

Abstract

Keywords

ASJC Scopus subject areas

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