Neurotransmitters in spinal cord injury

M. Rodriguez, V. Sahgal, V. Subramani

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The authors report the distribution of acetylcholinesterase activity and catecholamine fluorescence in the intact and completely transected rat spinal cord. The catecholamine terminals were scarce in the posterior horn and abundant in the intermediate and anterior horn regions. In the thoracic region, intense amine fluorescence was seen in the intermediolateral cell column. Spinal transection resulted in the enhancement of fluorescence above the lesion and disappearance below the lesion within seven days. The cholinesterase activity in the controls was found mostly in the anterior horn region and the tip of the posterior horn. Following transection, there was no significant change in the distribution of this enzyme. These changes correlated with the appearance of spasticity.

Original languageEnglish (US)
Pages (from-to)547-554
Number of pages8
JournalArchives of Physical Medicine and Rehabilitation
Issue number12
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Rehabilitation


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