Neurotensin agonists: Possible drugs for treatment of psychostimulant abuse

Elliott Richelson; Mona Boules; Paul Fredrickson

doi:10.1016/S0024-3205(03)00388-6

Neurotensin agonists: Possible drugs for treatment of psychostimulant abuse

Elliott Richelson, Mona Boules, Paul Fredrickson

Neuroscience

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Although many neuropeptides have been implicated in the pathophysiology of psychostimulant abuse, the tridecapeptide neurotensin holds a prominent position in this field due to the compelling literature on this peptide and psychostimulants. These data strongly support the hypothesis that a neurotensin agonist will be clinically useful to treat the abuse of psychostimulants, including nicotine. This paper reviews the evidence for a role for neurotensin in stimulant abuse and for a neurotensin agonist for its treatment.

Original language	English (US)
Pages (from-to)	679-690
Number of pages	12
Journal	Life Sciences
Volume	73
Issue number	6
DOIs	https://doi.org/10.1016/S0024-3205(03)00388-6
State	Published - Jun 27 2003

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/S0024-3205(03)00388-6

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title = "Neurotensin agonists: Possible drugs for treatment of psychostimulant abuse",

abstract = "Although many neuropeptides have been implicated in the pathophysiology of psychostimulant abuse, the tridecapeptide neurotensin holds a prominent position in this field due to the compelling literature on this peptide and psychostimulants. These data strongly support the hypothesis that a neurotensin agonist will be clinically useful to treat the abuse of psychostimulants, including nicotine. This paper reviews the evidence for a role for neurotensin in stimulant abuse and for a neurotensin agonist for its treatment.",

author = "Elliott Richelson and Mona Boules and Paul Fredrickson",

note = "Funding Information: This work was supported by the Mayo Foundation for Medical Education and Research and the Forrest C. Lattner Foundation, Inc. ",

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AU - Richelson, Elliott

AU - Boules, Mona

AU - Fredrickson, Paul

N1 - Funding Information: This work was supported by the Mayo Foundation for Medical Education and Research and the Forrest C. Lattner Foundation, Inc.

PY - 2003/6/27

Y1 - 2003/6/27

N2 - Although many neuropeptides have been implicated in the pathophysiology of psychostimulant abuse, the tridecapeptide neurotensin holds a prominent position in this field due to the compelling literature on this peptide and psychostimulants. These data strongly support the hypothesis that a neurotensin agonist will be clinically useful to treat the abuse of psychostimulants, including nicotine. This paper reviews the evidence for a role for neurotensin in stimulant abuse and for a neurotensin agonist for its treatment.

AB - Although many neuropeptides have been implicated in the pathophysiology of psychostimulant abuse, the tridecapeptide neurotensin holds a prominent position in this field due to the compelling literature on this peptide and psychostimulants. These data strongly support the hypothesis that a neurotensin agonist will be clinically useful to treat the abuse of psychostimulants, including nicotine. This paper reviews the evidence for a role for neurotensin in stimulant abuse and for a neurotensin agonist for its treatment.

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Neurotensin agonists: Possible drugs for treatment of psychostimulant abuse

Abstract

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