Neuronal Inclusions

D. W. Dickson, W. L. Lin

Research output: Chapter in Book/Report/Conference proceedingChapter


Neuronal inclusions are valuable histological features in establishing an accurate neuropathological diagnosis of neurodegenerative disorders, but they also have provided insight into the underlying molecular pathology of these disorders. This review provides an overview of the most common neuronal inclusions, both cytoplasmic and intranuclear, in the aging human brain and in a range of neurodegenerative disorders, focusing on their appearance with routine histological methods, as well as by immunohistochemistry and electron microscopy.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages15
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
StatePublished - Jan 1 2014


  • Aging
  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • FUS
  • Frontotemporal dementia
  • Huntington's disease
  • Lewy body
  • Neurofibrillary tangle
  • P62/sequestosome
  • Parkinson's disease
  • Pick's disease
  • TDP-43
  • Tau
  • Ubiquitin
  • α-synuclein

ASJC Scopus subject areas

  • General Medicine


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