Neuromyelitis optica with extensive active brain involvement: An autopsy study

Mohammed A. Almekhlafi, Arthur W. Clark, Claudia F. Lucchinetti, Yunyan Zhang, Christopher Power, Robert B. Bell

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objective: To describe the clinical, molecular, and neuropathological findings of a patientwith aquaporin 4-positive relapsing myelitis who developed extensive brain involvement followed by death. Design: Case report. Setting: Foothills Medical Center, Calgary, Alberta, Canada. Patient: A 51-year-old woman with neuromyelitis optica spectrum disorder. Results: Neuropathological examination disclosed neuromyelitis optica lesions, even in areas that appeared normal radiologically and grossly. Immunostaining confirmed the massive disintegration of astrocytes in the acute and chronic lesions, indicating that astrocytes are targeted early in the disease process. Induction of the immune response was demonstrated by reverse-transcriptase polymerase chain reaction analysis of relevant immune response genes. Conclusions: This article supports and supplements current concepts of astrocyte disintegration in neuromyelitis optica and of immune mechanisms in its pathogenesis.

Original languageEnglish (US)
Pages (from-to)508-512
Number of pages5
JournalArchives of neurology
Issue number4
StatePublished - Apr 1 2011

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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