Neuromyelitis Optica

Marcelo Matiello; Brian G. Weinshenker

doi:10.1002/9781118298633.ch15

Neuromyelitis Optica

Marcelo Matiello, Brian G. Weinshenker

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Neuromyelitis optica (NMO) is a severe idiopathic autoimmune disease of the central nervous system (CNS). Most NMO patients are seropositive for the highly specific autoantibody (NMO-IgG), which targets aquaporin-4. In vitro and in vivo studies have shown that NMO-IgG is not just a diagnostic biomarker for NMO; it is an essential component of NMO pathophysiology. In this chapter, we discuss the current status of the diagnosis and treatment of NMO and highlight that the understanding of NMO-IgG-driven mechanisms may lead to specific therapies in the near future.

Original language	English (US)
Title of host publication	Multiple Sclerosis and CNS Inflammatory Disorders
Publisher	Wiley-Blackwell
Pages	153-162
Number of pages	10
ISBN (Electronic)	9781118298633
ISBN (Print)	9780470673881
DOIs	https://doi.org/10.1002/9781118298633.ch15
State	Published - Aug 25 2014

Keywords

Aquaporin-4
Devic's disease
LETM
NMO-IgG
Neuromyelitis optica

ASJC Scopus subject areas

Medicine(all)

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10.1002/9781118298633.ch15

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title = "Neuromyelitis Optica",

abstract = "Neuromyelitis optica (NMO) is a severe idiopathic autoimmune disease of the central nervous system (CNS). Most NMO patients are seropositive for the highly specific autoantibody (NMO-IgG), which targets aquaporin-4. In vitro and in vivo studies have shown that NMO-IgG is not just a diagnostic biomarker for NMO; it is an essential component of NMO pathophysiology. In this chapter, we discuss the current status of the diagnosis and treatment of NMO and highlight that the understanding of NMO-IgG-driven mechanisms may lead to specific therapies in the near future.",

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AU - Matiello, Marcelo

AU - Weinshenker, Brian G.

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N2 - Neuromyelitis optica (NMO) is a severe idiopathic autoimmune disease of the central nervous system (CNS). Most NMO patients are seropositive for the highly specific autoantibody (NMO-IgG), which targets aquaporin-4. In vitro and in vivo studies have shown that NMO-IgG is not just a diagnostic biomarker for NMO; it is an essential component of NMO pathophysiology. In this chapter, we discuss the current status of the diagnosis and treatment of NMO and highlight that the understanding of NMO-IgG-driven mechanisms may lead to specific therapies in the near future.

AB - Neuromyelitis optica (NMO) is a severe idiopathic autoimmune disease of the central nervous system (CNS). Most NMO patients are seropositive for the highly specific autoantibody (NMO-IgG), which targets aquaporin-4. In vitro and in vivo studies have shown that NMO-IgG is not just a diagnostic biomarker for NMO; it is an essential component of NMO pathophysiology. In this chapter, we discuss the current status of the diagnosis and treatment of NMO and highlight that the understanding of NMO-IgG-driven mechanisms may lead to specific therapies in the near future.

KW - Aquaporin-4

KW - Devic's disease

KW - LETM

KW - NMO-IgG

KW - Neuromyelitis optica

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DO - 10.1002/9781118298633.ch15

M3 - Chapter

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SN - 9780470673881

SP - 153

EP - 162

BT - Multiple Sclerosis and CNS Inflammatory Disorders

PB - Wiley-Blackwell

ER -

Neuromyelitis Optica

Abstract

Keywords

ASJC Scopus subject areas

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