Neuromyelitis Optica

Marcelo Matiello, Brian G. Weinshenker

Research output: Chapter in Book/Report/Conference proceedingChapter


Neuromyelitis optica (NMO) is a severe idiopathic autoimmune disease of the central nervous system (CNS). Most NMO patients are seropositive for the highly specific autoantibody (NMO-IgG), which targets aquaporin-4. In vitro and in vivo studies have shown that NMO-IgG is not just a diagnostic biomarker for NMO; it is an essential component of NMO pathophysiology. In this chapter, we discuss the current status of the diagnosis and treatment of NMO and highlight that the understanding of NMO-IgG-driven mechanisms may lead to specific therapies in the near future.

Original languageEnglish (US)
Title of host publicationMultiple Sclerosis and CNS Inflammatory Disorders
Number of pages10
ISBN (Electronic)9781118298633
ISBN (Print)9780470673881
StatePublished - Aug 25 2014


  • Aquaporin-4
  • Devic's disease
  • LETM
  • NMO-IgG
  • Neuromyelitis optica

ASJC Scopus subject areas

  • Medicine(all)


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