Neurolymphomatosis: A report of 2 cases representing opposite ends of the clinical spectrum

Rajat Lahoria, P. James B. Dyck, William R. Macon, Brian A. Crum, Robert J. Spinner, Kimberly K. Amrami, Steven R. Zeldenrust, Jennifer A. Tracy

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Introduction: Neurolymphomatosis (NL) is a rare disorder characterized by invasion of cranial or peripheral nerves, nerve roots, or plexi, usually by aggressive subtypes of non-Hodgkin lymphoma (NHL). The most common clinical presentation is that of a painful polyneuropathy or polyradiculopathy, followed by cranial neuropathy and, less frequently, by painless polyneuropathy. Methods: Clinical and pathologic findings are reported for 2 NL cases. Results: The following 2 patients with NL, with disparate clinical presentations, are presented: a patient with subacute onset, painful, multifocal, mixed axonal and demyelinating radiculoplexus neuropathy due to a large B-cell NHL, who required 2 targeted fascicular nerve biopsies to demonstrate NL; and a patient with a slowly progressive, length-dependent axonal polyneuropathy due to a low-grade B-cell lymphoproliferative disorder, as shown on a diagnostic sural nerve biopsy. Conclusions: The cases described illustrate the wide clinical spectrum of NL.

Original languageEnglish (US)
Pages (from-to)449-454
Number of pages6
JournalMuscle and Nerve
Issue number3
StatePublished - Sep 1 2015


  • Lymphoproliferative disorder
  • Neurolymphomatosis
  • Neuropathy
  • Non-Hodgkin lymphoma
  • Radiculoneuropathy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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