Neurological prognostication of outcome in patients in coma after cardiac arrest

Andrea O. Rossetti, Alejandro A. Rabinstein, Mauro Oddo

Research output: Contribution to journalReview articlepeer-review

149 Scopus citations


Management of coma after cardiac arrest has improved during the past decade, allowing an increasing proportion of patients to survive, thus prognostication has become an integral part of post-resuscitation care. Neurologists are increasingly confronted with raised expectations of next of kin and the necessity to provide early predictions of long-term prognosis. During the past decade, as technology and clinical evidence have evolved, post-cardiac arrest prognostication has moved towards a multimodal paradigm combining clinical examination with additional methods, consisting of electrophysiology, blood biomarkers, and brain imaging, to optimise prognostic accuracy. Prognostication should never be based on a single indicator, although some variables have very low false positive rates for poor outcome, multimodal assessment provides resassurance about the reliability of a prognostic estimate by offering concordant evidence.

Original languageEnglish (US)
Pages (from-to)597-609
Number of pages13
JournalThe Lancet Neurology
Issue number6
StatePublished - May 1 2016

ASJC Scopus subject areas

  • Clinical Neurology


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