Neurological complications of steroids and of supportive care

Shannon Fortin Ensign, Alyx B. Porter

Research output: Chapter in Book/Report/Conference proceedingChapter


Corticosteroids are commonly employed within oncology primarily as either part of a direct treatment regimen or more broadly a supportive care modality. However, despite the widespread and well-established benefits of corticosteroids in these roles, a myriad of side effects can develop in correlation with the chronicity and/or dosage required in use. In particular, neurological side effects can be pronounced, leading to a limitation in their cumulative use and a concern for the potential significant impact on patient quality of life. Neurologic complications also arise during the care of patients with cancer as a direct consequence of additional supportive care medications, including antiepileptics, analgesics, antiemetics, and antidepressants in particular, or during the management of tumor-associated CNS vascular damage, including ischemic infarction or hemorrhagic injury. Here, we review the spectrum of corticosteroid-induced neurologic complications as well as the neurologic complications that arise secondary to supportive care measures of patients within oncology.

Original languageEnglish (US)
Title of host publicationNeurological Complications of Systemic Cancer and Antineoplastic Therapy
Number of pages9
ISBN (Electronic)9780128219768
ISBN (Print)9780128219775
StatePublished - Jan 1 2022


  • Corticosteroids
  • Depression
  • Insomnia
  • Myopathy
  • Neuropsychiatric
  • Oncology
  • Opioids
  • Pain
  • Patients
  • Seizures
  • Steroid

ASJC Scopus subject areas

  • General Medicine


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