Neurologic presentation of Erdheim-Chester disease

Cynthia L. Bodkin, Zbigniew K. Wszolek

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Erdheim-Chester disease is a rare, systemic histiocytosis that involves multiple organ systems and causes symmetric sclerosis of the metaphysis and diaphysis of the long bones. We present 2 cases and reviewed 108 patients reported in the literature who had neurologic manifestations of Erdheim - Chester disease. After eye involvement or diabetes insipidus, cerebellar symptoms were most frequently encountered, followed by tumor, headaches, cord compression, mental status change, seizures, and change in libido. A wide range of neurological symptoms can be seen in ECD. Therefore we hope the review brings more awareness about this disorder.

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalNeurologia i neurochirurgia polska
Issue number5
StatePublished - Nov 21 2006


  • Erdheim-Chester disease
  • Neurological symptoms
  • Non-Langerhans histiocytosis

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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