Neurologic manifestations of podophyllin toxicity

Christopher M. Filley; Neill R. Graff-Radford; Joseph R. Lacy; Mark A. Heitner; Michael P. Earnest

doi:10.1212/wnl.32.3.308

Neurologic manifestations of podophyllin toxicity

Christopher M. Filley, Neill R. Graff-Radford, Joseph R. Lacy, Mark A. Heitner, Michael P. Earnest

Neurology

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48 Scopus citations

Abstract

A young woman presented with podophyllin intoxication following topical application of podophyllin resin to genital condylomata acuminata. The disorder was marked by hallucinatory psychosis, bone marrow depression, and mild hepatic dysfunction. The psychosis and systemic disturbances resolved within 3 weeks, but were followed by autonomic and sensorimotor peripheral neuropathy. This case illustrates the transient central neurotoxicity and persistent peripheral neurotoxicity of podophyllin.

Original language	English (US)
Pages (from-to)	308-311
Number of pages	4
Journal	Neurology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1212/wnl.32.3.308
State	Published - Mar 1982

ASJC Scopus subject areas

Clinical Neurology

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title = "Neurologic manifestations of podophyllin toxicity",

abstract = "A young woman presented with podophyllin intoxication following topical application of podophyllin resin to genital condylomata acuminata. The disorder was marked by hallucinatory psychosis, bone marrow depression, and mild hepatic dysfunction. The psychosis and systemic disturbances resolved within 3 weeks, but were followed by autonomic and sensorimotor peripheral neuropathy. This case illustrates the transient central neurotoxicity and persistent peripheral neurotoxicity of podophyllin.",

author = "Filley, {Christopher M.} and Graff-Radford, {Neill R.} and Lacy, {Joseph R.} and Heitner, {Mark A.} and Earnest, {Michael P.}",

year = "1982",

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AU - Filley, Christopher M.

AU - Graff-Radford, Neill R.

AU - Lacy, Joseph R.

AU - Heitner, Mark A.

AU - Earnest, Michael P.

PY - 1982/3

Y1 - 1982/3

N2 - A young woman presented with podophyllin intoxication following topical application of podophyllin resin to genital condylomata acuminata. The disorder was marked by hallucinatory psychosis, bone marrow depression, and mild hepatic dysfunction. The psychosis and systemic disturbances resolved within 3 weeks, but were followed by autonomic and sensorimotor peripheral neuropathy. This case illustrates the transient central neurotoxicity and persistent peripheral neurotoxicity of podophyllin.

AB - A young woman presented with podophyllin intoxication following topical application of podophyllin resin to genital condylomata acuminata. The disorder was marked by hallucinatory psychosis, bone marrow depression, and mild hepatic dysfunction. The psychosis and systemic disturbances resolved within 3 weeks, but were followed by autonomic and sensorimotor peripheral neuropathy. This case illustrates the transient central neurotoxicity and persistent peripheral neurotoxicity of podophyllin.

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Neurologic manifestations of podophyllin toxicity

Abstract

ASJC Scopus subject areas

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