Neurologic manifestations of podophyllin toxicity

Christopher M. Filley, Neill R. Graff-Radford, Joseph R. Lacy, Mark A. Heitner, Michael P. Earnest

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


A young woman presented with podophyllin intoxication following topical application of podophyllin resin to genital condylomata acuminata. The disorder was marked by hallucinatory psychosis, bone marrow depression, and mild hepatic dysfunction. The psychosis and systemic disturbances resolved within 3 weeks, but were followed by autonomic and sensorimotor peripheral neuropathy. This case illustrates the transient central neurotoxicity and persistent peripheral neurotoxicity of podophyllin.

Original languageEnglish (US)
Pages (from-to)308-311
Number of pages4
Issue number3
StatePublished - Mar 1982

ASJC Scopus subject areas

  • Clinical Neurology


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