Neurofibrillary degeneration and microtubule associated protein tau.

S. H. Yen, W. K. Liu

Research output: Contribution to journalReview articlepeer-review


Alzheimer disease is characterized by neurofibrillary pathology containing paired helical filaments (PHF). These abnormal filaments consist of a modified form of microtubule associated protein tau. The modification involves phosphorylation. In this mini review, we summarize recent studies regarding the differences between normal tau and PHF-tau, focusing especially on the extent and the site of phosphorylation. We also discuss the mechanisms possible involved in the development of PHF.

Original languageEnglish (US)
Pages (from-to)357-366
Number of pages10
JournalChinese Journal of Physiology
Issue number4
StatePublished - 1992

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


Dive into the research topics of 'Neurofibrillary degeneration and microtubule associated protein tau.'. Together they form a unique fingerprint.

Cite this