Abstract
Alzheimer disease is characterized by neurofibrillary pathology containing paired helical filaments (PHF). These abnormal filaments consist of a modified form of microtubule associated protein tau. The modification involves phosphorylation. In this mini review, we summarize recent studies regarding the differences between normal tau and PHF-tau, focusing especially on the extent and the site of phosphorylation. We also discuss the mechanisms possible involved in the development of PHF.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 357-366 |
| Number of pages | 10 |
| Journal | Chinese Journal of Physiology |
| Volume | 35 |
| Issue number | 4 |
| State | Published - 1992 |
ASJC Scopus subject areas
- Physiology
- Physiology (medical)