Neural misdirection in congenital ocular fibrosis syndrome: Implications and pathogenesis

M. C. Brodsky, S. C. Pollock, E. G. Buckley

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


A child with congenital ocular fibrosis syndrome and oculocutaneous albinism displayed two distinct neural misdirection syndromes: synergistic divergence and Marcus Gunn jaw winking. This and other reported cases of misdirected innervation in patients with congenital fibrosis syndrome suggest that normal neuronal connections fail to become established early in development and that lack of innervation may underlie the pathologic features of the disorder. The prevailing concept of congenital fibrosis syndrome as a primary myopathy should be reconsidered.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalJournal of pediatric ophthalmology and strabismus
Issue number4
StatePublished - 1989

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology


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