Nesfatin-1; implication in stress and stress-associated anxiety and depression

T. L. Emmerzaal, T. Kozicz

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Nesfatin-1, derived from an 82-amino-acid peptide precursor protein nucleobindin-2 (NUCB2), is a highly conserved peptide across mammalian species. Initial functional and neuroanatomical studies on NUCB2/nesfatin-1 in the central nervous system have supported a role for NUCB2/nesfatin-1 as a novel satiety molecule. In recent years, however, it has become apparent that this neuropeptide is involved in various other processes, one of which is the stress response. Stress-associated activation of NUCB2/nesfatin-1 neurons, together with nesfatin-1's central actions in the brain, is indicative of its significance in the stress adaptation response. Interestingly, increasing body of evidence implicates also NUCB2/nesfatin-1 in various forms of stress-associated psychopathologies, such as anxiety and depression. In this review, we will outline evidence that has significantly broadened our understanding of the biological significance of NUCB2/nesfatin-1 far beyond to be only a hypothalamic peptide with potent anorexigenic actions. NUCB2/nesfatin-1 neurons in the brain seem to emerge as novel, integral regulators of the stress adaptation response.

Original languageEnglish (US)
Pages (from-to)6941-6948
Number of pages8
JournalCurrent pharmaceutical design
Issue number39
StatePublished - Dec 1 2013


  • Acute stress
  • Chronic stress
  • Energy metabolism
  • Human
  • Nucleobindin-2
  • Psychopathology
  • Rodent

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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