Nephrotoxicity of nonionic contrast media after cardiac angiography

Acute renal dysfunction after radiographic investigations with conventional radiocontrast media is a common cause of acute renal failure.^1,2 Recently, new radiocontrast agents with altered physical properties including lower osmolarity and nonionicity have been approved and are being increasingly used. The purpose of our investigation was to define the prevalence and associated risks for contrast nephropathy after cardiac angiography with iohexol (an agent with low osmolarity and nonionicity) in a large group of patients at high risk for radiocontrast renal injury.