Nephrolithiasis After Bariatric Surgery for Obesity

John C. Lieske, Rajiv Kumar, Maria L. Collazo-Clavell

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Surgical intervention has become an accepted therapeutic alternative for the patient with medically complicated obesity. Multiple investigators have reported significant and sustained weight loss after bariatric surgery that is associated with improvement of many weight-related medical comorbidities, and statistically significant decreased overall mortality for surgically treated as compared with medically treated subjects. Although the Roux-en-Y gastric bypass (RYGB) is considered an acceptably safe treatment, an increasing number of patients are being recognized with nephrolithiasis after this, the most common bariatric surgery currently performed. The main risk factor appears to be hyperoxaluria, although low urine volume and citrate concentrations may contribute. The incidence of these urinary risk factors among the total post-RYGB population is unknown, but may be more than previously suspected based on small pilot studies. The etiology of the hyperoxaluria is unknown, but may be related to subtle and seemingly subclinical fat malabsorption. Clearly, further study is needed, especially to define better treatment options than the standard advice for a low-fat, low-oxalate diet, and use of calcium as an oxalate binder.

Original languageEnglish (US)
Pages (from-to)163-173
Number of pages11
JournalSeminars in nephrology
Issue number2
StatePublished - Mar 2008


  • Bariatric surgery
  • Roux-en-Y gastric bypass
  • enteric hyperoxaluria
  • nephrolithiasis
  • obesity
  • oxalate

ASJC Scopus subject areas

  • Nephrology


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