Neovascularization after ischemic nerve injury

Hitoshi Nukada, Peter James Dyck

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Because angioneogenesis is associated with wound repair, neovascularization may play an important role in regeneration after nerve injury. This hypothesis was tested in the present study in which the number and distribution of endoneurial capillaries were determined 6 weeks after ischemic nerve injury. The density of capillaries was increased in the central fascicular regions of the distal sciatic and proximal tibial nerves at sites of ischemic injury. This was accompanied by a decrease in intercapillary distance. Neovascularization may be a response to ischemia or a consequence of nerve degeneration or regeneration, the mechanisms of which are poorly understood.

Original languageEnglish (US)
Pages (from-to)391-397
Number of pages7
JournalExperimental Neurology
Issue number2
StatePublished - May 1986

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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