Michael G. Sarr, Waldemar Uhl, Oliver Strobel, Markus W. Buchler, Carlos Fernández-Del Castillo, Gregory G. Tsiotos, C. Ross Carter, Clement W. Imrie

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Severe acute pancreatitis remains a life-threatening disease. The first phase (about 10-14 days) is characterized by formation of pancreatic and peripancreatic necrosis and development of a systemic inflammatory response syndrome. This systemic response to the pancreatic inflammation/necrosis causes early organ failure that necessitates intensive care therapy. In the second phase (after 2 weeks), the leading cause of morbidity and mortality is superinfection of necrosis with development of septic multiple organ failure. In the last 2 decades, treatment has evolved considerably, and with improved intensive care management, there is a worldwide trend toward a more conservative strategy with operative intervention initiated primarily because of the local and systemic manifestations of infected necrosis and less so for sterile necrosis. However, today, septic complications caused by pancreatic infection account for 80% of the mortality, and infected necrosis therefore usually remains an absolute indication for same form of invasive intervention.

Original languageEnglish (US)
Title of host publicationAtlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery
PublisherSpringer Berlin Heidelberg
Number of pages23
ISBN (Print)9783540200048
StatePublished - 2007

ASJC Scopus subject areas

  • Medicine(all)


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