Abstract
A novel class of hepatitis B virus mutants in patients with chronic hepatitis B is described. The predicted effect of the mutations is to disrupt the X open reading frame. The location of the genetic alterations within the putative precore promoter also suggests that they may ameliorate precore transcription, which would provide an alternate mechanism for HBeAg(-) escape variation. Definitive conclusions regarding the effects of these mutations must await additional in vitro and in vivo studies.
Original language | English (US) |
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Pages (from-to) | 837-841 |
Number of pages | 5 |
Journal | Journal of hepatology |
Volume | 20 |
Issue number | 6 |
DOIs | |
State | Published - 1994 |
Keywords
- Core promoter
- Deletion
- HBeAg
ASJC Scopus subject areas
- Hepatology