Natural orifice transluminal endoscopic surgery for patients with perforated peptic ulcer

Eduardo A. Bonin, Erica Moran, Christopher J. Gostout, Andrea L. McConico, Martin Zielinski, Juliane Bingener

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background Perforation accounts for 70% of deaths attributed to peptic ulcers. Laparoscopic repair is effective but infrequently used. Our aim was to assess how many patients with perforated peptic ulcer could be candidates for a transluminal endoscopic omental patch closure. Methods This retrospective study reviewed patients with perforated peptic ulcer from 2005 to 2010. Demographics, ulcer characteristics, operative procedure, and outcomes were recorded. Candidates for endoscopic transluminal repair were defined as those having undergone omental patch closure of an ulcer of appropriate size and no contraindications to laparoscopy or endoscopy. Results In the retrospective review, a total of 104 patients were identified; 62% female, mean age = 68 years, mean ASA of 3, and 63% medication-related ulcers. Fifty-nine (63%) had an omental patch (80% open), and 35 (37%) had other procedures. Ten patients had nonoperative management. Thirty-day mortality was 14% and 1 year mortality was 35%. Forty-nine patients (52%) were considered potential candidates for transluminal repair. Conclusion Sixty-three percent of our patients sustained a medication-related perforation with 1 year mortality of 35%. The majority of patients were treated using open omental patch repair. Transluminal endoscopic repair may provide an additional situation for a minimally invasive approach for a number of these patients.

Original languageEnglish (US)
Pages (from-to)1534-1538
Number of pages5
JournalSurgical endoscopy
Issue number6
StatePublished - Jun 2012


  • Acute abdomen
  • Minimally invasive procedure
  • Natural orifice transluminal endoscopic surgery
  • Peptic ulcer disease
  • Perforation

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Natural orifice transluminal endoscopic surgery for patients with perforated peptic ulcer'. Together they form a unique fingerprint.

Cite this