Nanoparticle Based Cardiac Specific Drug Delivery

Dong Li, Yura Son, Michelle Jang, Shu Wang, Wuqiang Zhu

Research output: Contribution to journalReview articlepeer-review


Heart failure secondary to myocardial injuries is a leading cause of death worldwide. Recently, a growing number of novel therapies have emerged for injured myocardium repairment. However, delivering therapeutic agents specifically to the injured heart remains a significant challenge. Nanoparticles are the most commonly used vehicles for targeted drug delivery. Various nanoparticles have been synthesized to deliver drugs and other therapeutic molecules to the injured heart via passive or active targeting approaches, and their targeting specificity and therapeutic efficacies have been investigated. Here, we summarized nanoparticle-based, cardiac-specific drug delivery systems, their potency for treating heart diseases, and the mechanisms underlying these cardiac-targeting strategies. We also discussed the clinical studies that have employed nanoparticle-based cardiac-specific drug delivery.

Original languageEnglish (US)
Article number82
Issue number1
StatePublished - Jan 2023


  • cardiac
  • ischemia
  • myocardial
  • nanomaterial
  • nanoparticle
  • targeted delivery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)


Dive into the research topics of 'Nanoparticle Based Cardiac Specific Drug Delivery'. Together they form a unique fingerprint.

Cite this