Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus

Myoung Hwa Lee; Hong Kim; Baek Vin Lim; Hyun Kyung Chang; Taeck Hyun Lee; Mi Hyeon Jang; Min Chul Shin; Jongseok Lee; Mal Soon Shin; Chang Ju Kim

doi:10.1016/j.lfs.2003.06.005

Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus

Myoung Hwa Lee, Hong Kim, Baek Vin Lim, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Jongseok Lee, Mal Soon Shin, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The expression of c-Fos is induced by a variety of stimuli and is sometimes used as a marker for increased neuronal activity. In the present study, the effect of treadmill running on c-Fos expression in the hippocampus and the involvement of opioid receptors were investigated via c-Fos immunohistochemistry. It was shown that c-Fos expression in the CA1 region, the CA2 and CA3 regions, and the dentate gyrus of the hippocampus was significantly increased by treadmill running and naloxone, a nonselective opioid receptors antagonist, treatment enhanced treadmill exercise-induced increase of hippocampal c-Fos expression. Base on the present results, it can be suggested that treadmill running increases hippocamal neuronal activity and that endogenous opioids curtail the exercise-induced increase.

Original language	English (US)
Pages (from-to)	3139-3147
Number of pages	9
Journal	Life Sciences
Volume	73
Issue number	24
DOIs	https://doi.org/10.1016/j.lfs.2003.06.005
State	Published - Oct 31 2003

Keywords

Hippocampus
Naloxone
Treadmill exercise
c-Fos immunohistochemistry

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/j.lfs.2003.06.005

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title = "Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus",

abstract = "The expression of c-Fos is induced by a variety of stimuli and is sometimes used as a marker for increased neuronal activity. In the present study, the effect of treadmill running on c-Fos expression in the hippocampus and the involvement of opioid receptors were investigated via c-Fos immunohistochemistry. It was shown that c-Fos expression in the CA1 region, the CA2 and CA3 regions, and the dentate gyrus of the hippocampus was significantly increased by treadmill running and naloxone, a nonselective opioid receptors antagonist, treatment enhanced treadmill exercise-induced increase of hippocampal c-Fos expression. Base on the present results, it can be suggested that treadmill running increases hippocamal neuronal activity and that endogenous opioids curtail the exercise-induced increase.",

keywords = "Hippocampus, Naloxone, Treadmill exercise, c-Fos immunohistochemistry",

author = "Lee, {Myoung Hwa} and Hong Kim and Lim, {Baek Vin} and Chang, {Hyun Kyung} and Lee, {Taeck Hyun} and Jang, {Mi Hyeon} and Shin, {Min Chul} and Jongseok Lee and Shin, {Mal Soon} and Kim, {Chang Ju}",

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doi = "10.1016/j.lfs.2003.06.005",

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T1 - Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus

AU - Lee, Myoung Hwa

AU - Kim, Hong

AU - Lim, Baek Vin

AU - Chang, Hyun Kyung

AU - Lee, Taeck Hyun

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lee, Jongseok

AU - Shin, Mal Soon

AU - Kim, Chang Ju

PY - 2003/10/31

Y1 - 2003/10/31

N2 - The expression of c-Fos is induced by a variety of stimuli and is sometimes used as a marker for increased neuronal activity. In the present study, the effect of treadmill running on c-Fos expression in the hippocampus and the involvement of opioid receptors were investigated via c-Fos immunohistochemistry. It was shown that c-Fos expression in the CA1 region, the CA2 and CA3 regions, and the dentate gyrus of the hippocampus was significantly increased by treadmill running and naloxone, a nonselective opioid receptors antagonist, treatment enhanced treadmill exercise-induced increase of hippocampal c-Fos expression. Base on the present results, it can be suggested that treadmill running increases hippocamal neuronal activity and that endogenous opioids curtail the exercise-induced increase.

AB - The expression of c-Fos is induced by a variety of stimuli and is sometimes used as a marker for increased neuronal activity. In the present study, the effect of treadmill running on c-Fos expression in the hippocampus and the involvement of opioid receptors were investigated via c-Fos immunohistochemistry. It was shown that c-Fos expression in the CA1 region, the CA2 and CA3 regions, and the dentate gyrus of the hippocampus was significantly increased by treadmill running and naloxone, a nonselective opioid receptors antagonist, treatment enhanced treadmill exercise-induced increase of hippocampal c-Fos expression. Base on the present results, it can be suggested that treadmill running increases hippocamal neuronal activity and that endogenous opioids curtail the exercise-induced increase.

KW - Hippocampus

KW - Naloxone

KW - Treadmill exercise

KW - c-Fos immunohistochemistry

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JO - Life Sciences

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ER -

Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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