Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus

Myoung Hwa Lee, Hong Kim, Baek Vin Lim, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Jongseok Lee, Mal Soon Shin, Chang Ju Kim

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The expression of c-Fos is induced by a variety of stimuli and is sometimes used as a marker for increased neuronal activity. In the present study, the effect of treadmill running on c-Fos expression in the hippocampus and the involvement of opioid receptors were investigated via c-Fos immunohistochemistry. It was shown that c-Fos expression in the CA1 region, the CA2 and CA3 regions, and the dentate gyrus of the hippocampus was significantly increased by treadmill running and naloxone, a nonselective opioid receptors antagonist, treatment enhanced treadmill exercise-induced increase of hippocampal c-Fos expression. Base on the present results, it can be suggested that treadmill running increases hippocamal neuronal activity and that endogenous opioids curtail the exercise-induced increase.

Original languageEnglish (US)
Pages (from-to)3139-3147
Number of pages9
JournalLife Sciences
Issue number24
StatePublished - Oct 31 2003


  • Hippocampus
  • Naloxone
  • Treadmill exercise
  • c-Fos immunohistochemistry

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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